Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.It occurs naturally in the peyote cactus (Lophophora williamsii), the San Pedro cactus (Echinopsis pachanoi), the Peruvian torch (Echinopsis peruviana),
and other members of the Cactaceae plant family. It is also found in small amounts in certain members of the Fabaceae (bean) family, including Acacia berlandieri. However those claims concerning Acacia species have been challenged and have been unsupported in additional analysis.
Potential medical usage of Mescaline
Mescaline has a wide array of suggested medical usage, including treatment of alcoholism and depression, due to these disorders having links to serotonin deficiencies. However, its status as a Schedule I controlled substance in the Convention on Psychotropic Substances limits availability of the drug to researchers. Because of this, very few studies concerning mescaline’s activity and potential therapeutic effects in humans have been conducted since the early 1970s.
Dependence and abuse potential
Mescaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of mescaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Mescaline presents cross-tolerance with all psychedelics, meaning that after the consumption of mescaline all psychedelics will have a reduced effect.
Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
- 5-MeO-xxT– The 5-MeO class of tryptamines can be unpredictable in their interactions
- Cannabis– Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Amphetamines– The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Cocaine– The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Tramadol– This combination can cause seizures due to the lowering of the threshold by Tramadol and the potential of Mescaline to cause seziures.